SCIENTISTS FIND 'VAMPIRE' BACTERIA THAT HAS A THIRST FOR HUMAN BLOOD
- Infectious bacteria make a beeline for blood, just like sharks, a new study found
- Salmonella, E. coli, and related bacteria can detect tiny amounts of blood serum
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Deadly bacteria of the world have been found to seek and feast on human blood.
Researchers at Washington State University (WSU) uncovered a new trait called 'bacterial vampirism' among bacteria like Salmonella and E. coli, which cause foodborne illnesses.
It has long been a mystery to how and why these microorganisms can move so deftly from the gut to the blood where they can be deadly.
The team found that these bacteria are attracted to the liquid part of blood, or serum, which contains nutrients the bacteria can use as food.
The pathogens can easily find where the serum is and enter the bloodstream through small cuts in the digestive system, which sometimes causes death from sepsis in people with inflammatory bowel disease.
Even the tiniest amount of blood is enough to attract vampiric bacteria, much like sharks with their famous ability to detect one drop of blood in 10 billion drops of water.
Co-author Arden Baylink, a professor at WSU’s College of Veterinary Medicine, said in a statement: 'Bacteria infecting the bloodstream can be lethal.
'We learned some of the bacteria that most commonly cause bloodstream infections actually sense a chemical in human blood and swim toward it.'
According to the new study, published in the journal eLife, enterobacteria like E. coli and Salmonella can detect as little as a femtoliter of serum - a tiny quantity equal to 0.0000000000001 milliliters.
Once they find the cut that's leaking the blood into the gut, they crowd around it and enter it.
It's a lot like how sharks can search out prey from their blood, but bacteria don't have noses so they rely on other senses.
The team used a high-powered microscope system to simulate intestinal bleeding by injecting microscopic amounts of human serum and watching as the bacteria navigated toward the source.
They watched as the microbes searched for the serum, finding it took less than one minute.
In this case, it's a strategy called 'chemotaxis,' where bacteria move toward higher concentrations of specific substances.
The team also determined Salmonella has a special protein receptor called Tsr that enables bacteria to sense and swim toward serum.
In the discovery of Tsr, researchers used a form high-resolution microscopy to view the atoms of the protein interacting with serine.
The scientists believe serine is one of the chemicals from blood that the bacteria sense and consume.
This new understanding of how bacteria can home in on the bloodstream paves the way for new drugs that will prevent sepsis before it even happens, rather than treating it once someone is sick, the scientists behind the new study said.
'By learning how these bacteria are able to detect sources of blood, in the future we could develop new drugs that block this ability. These medicines could improve the lives and health of people with inflammatory bowel disease who are at high risk for bloodstream infections, said Ph.D. student Siena Glenn, a study co-author.
Usually, intestinal infections are resolved by the immune system without serious problems - maybe a touch of diarrhea.
But people who have inflammatory bowel disease, including Crohn's disease and ulcerative colitis, are at much higher risk of developing bleeds inside their bowel - which can let bacteria enter the bloodstream, causing a more serious bacterial infection.
This puts them at particularly high risk of developing a condition called sepsis, which is essentially a chain reaction of the immune system attacking the body in response to an infection.
Understanding exactly why gut bacteria are adept at entering the bloodstream through tiny tears or cuts in the bowel can help scientists prevent serious illness in people with these chronic conditions.
Under normal circumstances, there are populations of bacteria in our gut that are often considered harmful - like E. coli and salmonella.
They are kept in check by other bacteria and our immune systems when we are healthy.
But if they enter our bloodstream, they can lead to sepsis.
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