Anemia is either due to decreased red blood cells or decreased hemoglobin or both. For the production of RBC, the enzyme erythropoietin is needed. Erythropoietin is produced from kidneys, in kidney injury, this enzyme is decreased. In some types of kidney diseases, red blood cells and hemoglobin filtered and excreted in the urine causes anemia. Repeated blood tests, dialysis increases blood loss. Kidney disease decreases appetite.
Kidney normally secrete erythropoietin hormone. So, in kidney diseases this hormone is not produced resulting in decrease production of red blood cells. In chronic kidney diseases sometimes blood is also filtered due to damage to glomerulus endothelium. In kidney failure patients who are on dialysis also has anemia.
Erythropoietin is a hormone produced mainly by the kidneys, it is related to the formation of red blood cells. Patients with chronic kidney disease have impaired renal function, less erythropoietin and consequently anemia in more advanced disease states.
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