Crohn’s disease is a form of inflammatory bowel disease that can cause inflammation in any part of the digestive tract. Complications of Crohn’s disease include: • an abnormal connection (called a fistula) between the two parts of the intestine or between the intestine and the skin, bladder or other parts of the body • perforation of the intestine • infection, such as an intestinal abscess • poor nutrient absorption leading to weight loss, vitamin deficiency and weak bones • arthritis • eye inflammation • skin abnormalities (called erythema nodosum or pyoderma gangrenosum) • inflammation of bile ducts in the liver • amyloidosis, in which amyloid protein accumulates in the kidneys or other organs • kidney stones • lung inflammation and scarring • anemia
Crohn's disease is characterized by a chronic inflammation that can affect any part of the digestive tract, generating several complications, the most common being intestinal obstruction, abscesses, fistulas, fissures, malabsorption and malnutrition, intestinal flora imbalance and diarrhea.
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The genetic variations in Chron’s disease are mainly seen in chromosomes 5 and 16. The karyotype is 46XiXq. This in pure or mosaic form is a single susceptibility factor for Chron’s disease.
Liver and/or gallbladder disease, arthritis, skin disorders, anemia and osteoporosis are complications of Crohn's disease.
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